The mission of Flutterby Consultants is to help our clients navigate the drug discovery process from target selection to IND submission, with a focus on medicinal chemistry
Flutterby Consultants can provide expertise in the following areas
Strategy
Target selection
Strategy
Landscaping
Screening cascades
Contract Research Organizations (CROs)
Finding the right CRO
CRO oversight
Troubleshooting
Non-GMP scale up
Hit Identification
Screening technologies
Screening library
Hit validation
Identification of false positives
Lead Identification
Analysis of HTS results
Analysis of DEL results
Clustering
Prioritization of most promising compounds
SAR by catalogue
Design of small libraries to explore SAR
Lead Optimization
Multiparameter optimization
Optimization of ADME properties
Minimization of potential safety liabilities
Intellectual Property
IP landscaping
Identification of gaps
Experimentals for patent applications
Close collaboration with patent attorneys/patent agents
Paul Gillespie is a seasoned drug discovery professional with more than 30 years of experience as a medicinal chemist at Hoffmann-La Roche, Roche TCRC, and Exelixis. As a member of the leadership team for medicinal chemistry at Roche Nutley, and of the Discovery Leadership team at Exelixis, Paul led teams to the discovery of 5 compounds that have entered the clinic. Paul has experience throughout the drug discovery timeline from target selection to involvement in non-GLP tox studies. Paul has experience in structure-based drug design using MOE, LiveDesign and Chemistry 42, and extensive experience in cheminformatics using Pipeline Pilot. Paul founded and led the hit-to-lead team at Roche Nutley for more than a decade, overseeing the triage of 47 high-throughput screens. Paul was the chemistry representative for more than 35 due diligences, several of which led to drugs entering the clinic. Paul's innovation and scientific leadership have led to 35 scientific publications and 45 patent applications.
Get in touch by email at info@flutterby.ai to arrange an introductory call. The initial meeting is free and we can establish how Flutterby Consultants can help you help patients.