Flutterby Consultants Inc
The mission of Flutterby Consultants is to help our clients navigate the drug discovery process from target selection to IND submission, with a focus on medicinal chemistry
Flutterby Consultants can provide expertise in the following areas
Strategy
  • Target selection
  • Strategy
  • Landscaping
  • Screening cascades
Contract Research Organizations (CROs)
  • Finding the right CRO
  • CRO oversight
  • Troubleshooting
  • Non-GMP scale up
Hit Identification
  • Screening technologies
  • Screening library
  • Hit validation
  • Identification of false positives
Lead Identification
  • Analysis of HTS results
  • Analysis of DEL results
  • Clustering
  • Prioritization of most promising compounds
  • SAR by catalogue
  • Design of small libraries to explore SAR
Lead Optimization
  • Multiparameter optimization
  • Optimization of ADME properties
  • Minimization of potential safety liabilities
Intellectual Property
  • IP landscaping
  • Identification of gaps
  • Experimentals for patent applications
  • Close collaboration with patent attorneys/patent agents
Paul Gillespie is a seasoned drug discovery professional with more than 30 years of experience as a medicinal chemist at Hoffmann-La Roche, Roche TCRC, and Exelixis. As a member of the leadership team for medicinal chemistry at Roche Nutley, and of the Discovery Leadership team at Exelixis, Paul led teams to the discovery of 5 compounds that have entered the clinic. Paul has experience throughout the drug discovery timeline from target selection to involvement in non-GLP tox studies. Paul has experience in structure-based drug design using MOE, LiveDesign and Chemistry 42, and extensive experience in cheminformatics using Pipeline Pilot. Paul founded and led the hit-to-lead team at Roche Nutley for more than a decade, overseeing the triage of 47 high-throughput screens. Paul was the chemistry representative for more than 35 due diligences, several of which led to drugs entering the clinic. Paul's innovation and scientific leadership have led to 35 scientific publications and 45 patent applications.
Get in touch by email at info@flutterby.ai to arrange an introductory call. The initial meeting is free and we can establish how Flutterby Consultants can help you help patients.